Retinal research is moving at a very fast rate. Moreover, the eye is an excellent target for therapy being an accessible, highly compartimentalized, relatively isolated, and easy-to-test neural tissue. Advances in therapies for visual disorders are continuously emerging and a number of therapies are now in clinical trials.

Literature references to follow the advances in this field are shown below:

Results at 2 Years after Gene Therapy for RPE65-Deficient Leber Congenital Amaurosis and Severe Early-Childhood-Onset Retinal Dystrophy. Weleber et al. American Academy of Ophthalmology. 2016

Treatment of Macular Degeneration Using Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Preliminary Results in Asian Patients. Kyung Song et al. Stem Cell Reports Vol. 4 pp 860–872, 2015

Promising results in a gene therapy trial for retinal disease. Nature Reviews Neurology Research Highlights 10, 123 (2014)

Gene therapy for retinal disease. McClements & MacLaren. Translational Research Volume 161, Number 4, 241-250

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial. MacLaren et al. Lancet 2014; 383: 1129–37

Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases. Wiley et al. Progress in Retinal and Eye Research Vol 44, pp 15–35, 2015